Assay Detail
Binding
CHEMBL1049083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.46 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565745 | — | — | 1 | 7.36 |
| CHEMBL584046 | — | — | 1 | 6.32 |
| CHEMBL571858 | — | — | 1 | 6.19 |
| CHEMBL565552 | — | — | 1 | 5.95 |
| CHEMBL576315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565745 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL584046 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL571858 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL565552 | — | IC50 | = | 1135.0 | nM | 5.95 |
| CHEMBL576315 | — | IC50 | > | 5000.0 | nM | - |