Assay Detail
Binding
CHEMBL1049320
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Inhibition of Pseudomonas aeruginosa LasR
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Transcriptional activator protein LasR (CHEMBL1075207) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Theoretical and structural analysis of the active site of the transcriptional regulators LasR and TraR, using molecular docking methodology for identifying potential analogues of acyl homoserine lactones (AHLs) with anti-quorum sensing activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.53 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573744 | — | — | 1 | 4.83 |
| CHEMBL575294 | — | — | 1 | 4.79 |
| CHEMBL573745 | — | — | 1 | 4.48 |
| CHEMBL584972 | — | — | 1 | 4.29 |
| CHEMBL473592 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573744 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL575294 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL573745 | — | IC50 | = | 33100.0 | nM | 4.48 |
| CHEMBL584972 | — | IC50 | = | 51500.0 | nM | 4.29 |
| CHEMBL473592 | — | IC50 | = | 53600.0 | nM | 4.27 |