Assay Detail
Binding
CHEMBL1049476
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Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetry
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A single step purification for autolytic zinc proteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.81 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | — | 1 | 8.15 |
| CHEMBL114272 | — | — | 1 | 7.37 |
| CHEMBL38851 | — | — | 1 | 6.96 |
| CHEMBL591321 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514138 | CGS-27023A | Kd | = | 7.0 | nM | 8.15 |
| CHEMBL114272 | — | Kd | = | 43.0 | nM | 7.37 |
| CHEMBL38851 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL591321 | — | Kd | = | 17000.0 | nM | 4.77 |