Assay Detail
Functional
CHEMBL1049488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunosuppressive activity in C57BL/6 mouse lymphocytes cocultured with mitomycin C-stimulated BALB/c mouse splenocyte assessed as [3H]thymidine incorporation after 72 hrs by mixed lymphocyte reaction
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.89 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL591325 | — | — | 1 | 9.13 |
| CHEMBL591326 | — | — | 1 | 9.07 |
| CHEMBL596079 | — | — | 1 | 8.96 |
| CHEMBL601096 | — | — | 1 | 8.92 |
| CHEMBL595401 | — | — | 1 | 8.89 |
| CHEMBL591324 | — | — | 1 | 8.89 |
| CHEMBL600873 | — | — | 1 | 8.82 |
| CHEMBL596078 | — | — | 1 | 8.36 |
| CHEMBL591322 | — | — | 1 | 8.19 |
| CHEMBL603859 | — | — | 1 | 8.17 |
| CHEMBL595624 | — | — | 1 | 8.09 |
| CHEMBL591091 | — | — | 1 | 8.08 |
| CHEMBL592262 | — | — | 1 | 7.92 |
| CHEMBL592260 | — | — | 1 | 7.92 |
| CHEMBL591793 | — | — | 1 | 7.82 |
| CHEMBL591559 | — | — | 1 | 7.80 |
| CHEMBL582959 | — | — | 1 | 7.68 |
| CHEMBL595625 | — | — | 1 | 7.64 |
| CHEMBL607366 | — | — | 1 | 7.60 |
| CHEMBL595398 | — | — | 1 | 7.42 |
| CHEMBL592267 | — | — | 1 | 7.30 |
| CHEMBL606459 | — | — | 1 | 7.28 |
| CHEMBL592261 | — | — | 1 | 7.24 |
| CHEMBL592507 | — | — | 1 | 7.21 |
| CHEMBL603737 | — | — | 1 | 7.06 |
| CHEMBL604694 | — | — | 1 | 6.75 |
| CHEMBL592026 | — | — | 1 | 6.52 |
| CHEMBL592505 | — | — | 1 | 6.21 |
| CHEMBL605724 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL591325 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL591326 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL596079 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL601096 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL595401 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL591324 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL600873 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL596078 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL591322 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL603859 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL595624 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL591091 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL592262 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL592260 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL591793 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL591559 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL582959 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL595625 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL607366 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL595398 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL592267 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL606459 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL592261 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL592507 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL603737 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL604694 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL592026 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL592505 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL605724 | — | IC50 | > | 1000.0 | nM | - |