Assay Detail
Binding
CHEMBL1049504
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Inhibition of N-terminal hexahistidine tagged HCV 1b NS5B polymerase expressed in baculovirus infected Sf21 cells after 90 mins by SPA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Cell Type | Sf21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.45 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366574 | — | — | 1 | 7.72 |
| CHEMBL590373 | — | — | 1 | 7.22 |
| CHEMBL605616 | — | — | 1 | 7.05 |
| CHEMBL594318 | — | — | 1 | 7.00 |
| CHEMBL590850 | — | — | 1 | 6.89 |
| CHEMBL590851 | — | — | 1 | 6.55 |
| CHEMBL376487 | — | — | 1 | 6.52 |
| CHEMBL591089 | — | — | 1 | 6.47 |
| CHEMBL603143 | — | — | 1 | 6.44 |
| CHEMBL591560 | — | — | 1 | 6.41 |
| CHEMBL601480 | — | — | 1 | 6.40 |
| CHEMBL594592 | — | — | 1 | 6.35 |
| CHEMBL592027 | — | — | 1 | 6.05 |
| CHEMBL591090 | — | — | 1 | 6.05 |
| CHEMBL591792 | — | — | 1 | 5.82 |
| CHEMBL590848 | — | — | 1 | 5.79 |
| CHEMBL264034 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366574 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL590373 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL605616 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL594318 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL590850 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL590851 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL376487 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL591089 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL603143 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL591560 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL601480 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL594592 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL592027 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL591090 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL591792 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL590848 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL264034 | — | IC50 | = | 14000.0 | nM | 4.85 |