Assay Detail
Binding
CHEMBL1049523
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Inhibition of MAO-A in rat liver homogenate by spectrophotometry-based Holt method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] A (CHEMBL3358) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Towards development of selective and reversible pyrazoline based MAO-inhibitors: Synthesis, biological evaluation and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.92 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 8.30 |
| CHEMBL590369 | — | — | 1 | 6.44 |
| CHEMBL604171 | — | — | 1 | 6.22 |
| CHEMBL601479 | — | — | 1 | 6.17 |
| CHEMBL601717 | — | — | 1 | 6.10 |
| CHEMBL600672 | — | — | 1 | 6.04 |
| CHEMBL601269 | — | — | 1 | 5.43 |
| CHEMBL590120 | — | — | 1 | 5.41 |
| CHEMBL591088 | — | — | 1 | 5.24 |
| CHEMBL590606 | — | — | 1 | 4.97 |
| CHEMBL600856 | — | — | 1 | 4.80 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86304 | MOCLOBEMIDE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL590369 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL604171 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL601479 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL601717 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL600672 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL601269 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL590120 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL591088 | — | Ki | = | 5770.0 | nM | 5.24 |
| CHEMBL590606 | — | Ki | = | 10600.0 | nM | 4.97 |
| CHEMBL600856 | — | Ki | = | 15660.0 | nM | 4.80 |
| CHEMBL972 | SELEGILINE | Ki | = | 105660.0 | nM | - |