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Assay Detail

CHEMBL1050398

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HepG2 cells after 72 hrs
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of halo-nitrobenzamides with potential application against human African trypanosomiasis.
Hwang JY, Smithson D, Connelly M, Maier J, Zhu F, Guy KR.
Bioorg Med Chem Lett (2010) 20 : 149 -152
PubMed 19963377 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.30 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL603826 1 5.60
CHEMBL585463 1 4.99
CHEMBL592253 1 -
CHEMBL592497 1 -
CHEMBL591312 1 -
CHEMBL585955 1 -
CHEMBL602995 1 -
CHEMBL592499 1 -
CHEMBL602546 1 -
CHEMBL591314 1 -
CHEMBL591315 1 -
CHEMBL592736 1 -
CHEMBL602996 1 -
CHEMBL591551 1 -
CHEMBL591552 1 -
CHEMBL601093 1 -
CHEMBL591784 1 -
CHEMBL589129 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL603826 IC50 = 2500.0 nM 5.60
CHEMBL585463 IC50 = 10300.0 nM 4.99
CHEMBL592253 IC50 > 50000.0 nM -
CHEMBL592497 IC50 > 50000.0 nM -
CHEMBL591312 IC50 > 50000.0 nM -
CHEMBL585955 IC50 > 50000.0 nM -
CHEMBL602995 IC50 > 50000.0 nM -
CHEMBL592499 IC50 > 50000.0 nM -
CHEMBL602546 IC50 > 50000.0 nM -
CHEMBL591314 IC50 > 50000.0 nM -
CHEMBL591315 IC50 > 50000.0 nM -
CHEMBL592736 IC50 > 50000.0 nM -
CHEMBL602996 IC50 > 50000.0 nM -
CHEMBL591551 IC50 > 50000.0 nM -
CHEMBL591552 IC50 > 50000.0 nM -
CHEMBL601093 IC50 > 50000.0 nM -
CHEMBL591784 IC50 > 50000.0 nM -
CHEMBL589129 IC50 > 50000.0 nM -