Assay Detail
Binding
CHEMBL1050683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureido)-1H-pyrazol-1-yl)phenylamino)acetamide) from inactive form of JNK2 by enzyme fragment complementation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Displacement assay for the detection of stabilizers of inactive kinase conformations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.47 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.57 |
| CHEMBL522387 | — | — | 1 | 7.16 |
| CHEMBL570904 | — | — | 1 | 7.00 |
| CHEMBL585902 | AMG-548 | 1.0 | 1 | 6.66 |
| CHEMBL568875 | — | — | 1 | 6.36 |
| CHEMBL497033 | — | — | 1 | 6.11 |
| CHEMBL497615 | — | — | 1 | 5.92 |
| CHEMBL101035 | — | — | 1 | 5.75 |
| CHEMBL569943 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL522387 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL570904 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL585902 | AMG-548 | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL568875 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL497033 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL497615 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL101035 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL569943 | — | IC50 | = | 1900.0 | nM | 5.72 |