Assay Detail
Binding
CHEMBL1050684
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Inhibition of JNK2 active form by HTRF assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Displacement assay for the detection of stabilizers of inactive kinase conformations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.35 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL585902 | AMG-548 | 1.0 | 1 | 7.12 |
| CHEMBL522387 | — | — | 1 | 7.05 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 6.82 |
| CHEMBL497615 | — | — | 1 | 6.82 |
| CHEMBL570904 | — | — | 1 | 6.42 |
| CHEMBL497033 | — | — | 1 | 6.24 |
| CHEMBL568875 | — | — | 1 | 5.89 |
| CHEMBL569943 | — | — | 1 | 5.85 |
| CHEMBL101035 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL585902 | AMG-548 | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL522387 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL497615 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL570904 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL497033 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL568875 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL569943 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL101035 | — | IC50 | = | 12600.0 | nM | 4.90 |