Assay Detail
Binding
CHEMBL1050690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 8.11 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571767 | — | — | 1 | 10.52 |
| CHEMBL49269 | CYCLORPHAN | — | 1 | 10.47 |
| CHEMBL568757 | — | — | 1 | 10.33 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 10.10 |
| CHEMBL571998 | — | — | 1 | 9.47 |
| CHEMBL568877 | — | — | 1 | 9.29 |
| CHEMBL571990 | — | — | 1 | 9.23 |
| CHEMBL570429 | — | — | 1 | 9.22 |
| CHEMBL585901 | — | — | 1 | 9.21 |
| CHEMBL568876 | — | — | 1 | 9.10 |
| CHEMBL570654 | — | — | 1 | 9.00 |
| CHEMBL570225 | — | — | 1 | 8.82 |
| CHEMBL571561 | — | — | 1 | 8.80 |
| CHEMBL571560 | — | — | 1 | 8.55 |
| CHEMBL568988 | — | — | 1 | 8.41 |
| CHEMBL569215 | — | — | 1 | 8.31 |
| CHEMBL568989 | — | — | 1 | 8.28 |
| CHEMBL576273 | — | — | 1 | 8.24 |
| CHEMBL569725 | — | — | 1 | 7.92 |
| CHEMBL571322 | — | — | 1 | 7.89 |
| CHEMBL568813 | — | — | 1 | 7.80 |
| CHEMBL572217 | — | — | 1 | 7.58 |
| CHEMBL570428 | — | — | 1 | 7.58 |
| CHEMBL572216 | — | — | 1 | 7.55 |
| CHEMBL569009 | — | — | 1 | 7.52 |
| CHEMBL568758 | — | — | 1 | 7.51 |
| CHEMBL569313 | — | — | 1 | 7.43 |
| CHEMBL569448 | — | — | 1 | 7.40 |
| CHEMBL570449 | — | — | 1 | 7.40 |
| CHEMBL568071 | — | — | 1 | 7.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571767 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL49269 | CYCLORPHAN | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL568757 | — | Ki | = | 0.047 | nM | 10.33 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL571998 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL568877 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL571990 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL570429 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL585901 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL568876 | — | Ki | = | 0.79 | nM | 9.10 |
| CHEMBL570654 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL570225 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL571561 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL571560 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL568988 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL569215 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL568989 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL576273 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL569725 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL571322 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL568813 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL570428 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL572217 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL572216 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL569009 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL568758 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL569313 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL569448 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL570449 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL568071 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL566128 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL567170 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL584530 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL568878 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL568830 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL569724 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL576065 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL568829 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL583265 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL578173 | — | Ki | = | 380.0 | nM | 6.42 |