Assay Detail
Binding
CHEMBL1050788
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Inhibition of human recombinant COX2 by enzyme immunoassay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.87 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.92 |
| CHEMBL568723 | — | — | 1 | 6.05 |
| CHEMBL567160 | — | — | 1 | 6.05 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.96 |
| CHEMBL577045 | — | — | 1 | 5.75 |
| CHEMBL577482 | — | — | 1 | 5.64 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.62 |
| CHEMBL568719 | — | — | 1 | 5.46 |
| CHEMBL568715 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL568723 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL567160 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL577045 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL577482 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL25 | ASPIRIN | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL568719 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL568715 | — | IC50 | = | 4600.0 | nM | 5.34 |