Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1050857

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant GR after 15 mins in presence of NADPH
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glutathione reductase, mitochondrial (CHEMBL2755)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ.
J Med Chem (2009) 52 : 6474 -6483
PubMed 19761212 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.41 4.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL570130 1 4.45
CHEMBL567637 1 4.45
CHEMBL571712 1 4.34
CHEMBL565242 1 -
CHEMBL574801 1 -
CHEMBL570132 1 -
CHEMBL578810 1 -
CHEMBL569188 1 -
CHEMBL568961 1 -
CHEMBL576118 1 -
CHEMBL567408 1 -
CHEMBL585368 1 -
CHEMBL574579 1 -
CHEMBL585190 1 -
CHEMBL570346 1 -
CHEMBL571710 1 -
CHEMBL500868 1 -
CHEMBL567641 1 -
CHEMBL574577 1 -
CHEMBL574360 1 -
CHEMBL575013 1 -
CHEMBL336467 FUROXAN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL570130 IC50 = 35700.0 nM 4.45
CHEMBL567637 IC50 = 35200.0 nM 4.45
CHEMBL571712 IC50 = 45300.0 nM 4.34
CHEMBL565242 IC50 > 50000.0 nM -
CHEMBL574801 IC50 > 50000.0 nM -
CHEMBL570132 IC50 > 50000.0 nM -
CHEMBL578810 IC50 > 50000.0 nM -
CHEMBL569188 IC50 > 50000.0 nM -
CHEMBL568961 IC50 > 50000.0 nM -
CHEMBL576118 IC50 > 50000.0 nM -
CHEMBL567408 IC50 > 50000.0 nM -
CHEMBL585368 IC50 > 50000.0 nM -
CHEMBL574579 IC50 > 50000.0 nM -
CHEMBL585190 IC50 > 50000.0 nM -
CHEMBL570346 IC50 > 50000.0 nM -
CHEMBL571710 IC50 > 50000.0 nM -
CHEMBL500868 IC50 > 50000.0 nM -
CHEMBL567641 IC50 > 50000.0 nM -
CHEMBL574577 IC50 > 50000.0 nM -
CHEMBL574360 IC50 > 50000.0 nM -
CHEMBL575013 IC50 > 50000.0 nM -
CHEMBL336467 FUROXAN IC50 > 50000.0 nM -