Assay Detail
Binding
CHEMBL1050899
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Inhibition of PTPN6
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.28 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342478 | — | — | 1 | 4.80 |
| CHEMBL341806 | — | — | 1 | 4.55 |
| CHEMBL342612 | — | — | 1 | 4.22 |
| CHEMBL336908 | — | — | 1 | 4.10 |
| CHEMBL573989 | — | — | 1 | 4.03 |
| CHEMBL138152 | — | — | 1 | 4.00 |
| CHEMBL577144 | — | — | 1 | - |
| CHEMBL138806 | — | — | 1 | - |
| CHEMBL139050 | — | — | 1 | - |
| CHEMBL336879 | — | — | 1 | - |
| CHEMBL139393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342478 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL341806 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL342612 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL336908 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL573989 | — | Ki | = | 94000.0 | nM | 4.03 |
| CHEMBL138152 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL577144 | — | Ki | = | 289000.0 | nM | - |
| CHEMBL138806 | — | Ki | = | 350000.0 | nM | - |
| CHEMBL139050 | — | Ki | = | 510000.0 | nM | - |
| CHEMBL336879 | — | Ki | > | 2000000.0 | nM | - |
| CHEMBL139393 | — | Ki | > | 2000000.0 | nM | - |