Assay Detail
Binding
CHEMBL1050900
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Inhibition of PTPRB
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Receptor-type tyrosine-protein phosphatase beta (CHEMBL2706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.87 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341806 | — | — | 1 | 5.44 |
| CHEMBL342478 | — | — | 1 | 5.22 |
| CHEMBL138806 | — | — | 1 | 4.96 |
| CHEMBL573989 | — | — | 1 | 4.85 |
| CHEMBL336908 | — | — | 1 | 4.77 |
| CHEMBL342612 | — | — | 1 | 4.75 |
| CHEMBL138152 | — | — | 1 | 4.72 |
| CHEMBL577144 | — | — | 1 | 4.68 |
| CHEMBL139050 | — | — | 1 | 4.48 |
| CHEMBL336879 | — | — | 1 | - |
| CHEMBL139393 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341806 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL342478 | — | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL138806 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL573989 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL336908 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL342612 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL138152 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL577144 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL139050 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL336879 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL139393 | — | Ki | = | 560000.0 | nM | - |