Assay Detail
Binding
CHEMBL1050929
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Inhibition of Plasmodium falciparum plasmepsin-4
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.62 | 4.92 |
| IC50 | 1 | 7.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231522 | — | — | 1 | 7.82 |
| CHEMBL436755 | — | — | 1 | 4.92 |
| CHEMBL198645 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231522 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL436755 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL198645 | — | Ki | = | 48000.0 | nM | 4.32 |