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Assay Detail

CHEMBL1051508

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Functional
Cytotoxicity against P-glycoprotein deficient wild type human MCF7 cells after 72 hrs
ChEMBL ↗
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Recent advances in the chemistry and biology of new generation taxoids.
Ojima I, Das M.
J Nat Prod (2009) 72 : 554 -565
PubMed 19239240 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 9.21 10.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL556526 — — 1 10.11
CHEMBL553663 — — 1 10.11
CHEMBL558360 — — 1 10.04
CHEMBL553113 — — 1 10.04
CHEMBL555697 — — 1 10.04
CHEMBL549678 — — 1 10.00
CHEMBL541440 — — 1 9.92
CHEMBL539891 — — 1 9.92
CHEMBL552530 — — 1 9.92
CHEMBL551337 — — 1 9.89
CHEMBL501006 — — 1 9.77
CHEMBL555142 — — 1 9.77
CHEMBL126678 — — 1 9.74
CHEMBL539196 — — 1 9.72
CHEMBL507683 — — 1 9.70
CHEMBL126916 — — 1 9.70
CHEMBL564422 — — 1 9.59
CHEMBL506225 — — 1 9.52
CHEMBL502400 — — 1 9.52
CHEMBL553933 — — 1 9.51
CHEMBL554777 — — 1 9.51
CHEMBL556740 — — 1 9.49
CHEMBL553932 — — 1 9.49
CHEMBL555946 — — 1 9.49
CHEMBL538440 — — 1 9.49
CHEMBL553898 — — 1 9.47
CHEMBL554541 — — 1 9.47
CHEMBL540215 — — 1 9.47
CHEMBL420349 — — 1 9.46
CHEMBL467163 — — 1 9.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL556526 — IC50 = 0.078 nM 10.11
CHEMBL553663 — IC50 = 0.078 nM 10.11
CHEMBL558360 — IC50 = 0.092 nM 10.04
CHEMBL553113 — IC50 = 0.092 nM 10.04
CHEMBL555697 — IC50 = 0.092 nM 10.04
CHEMBL549678 — IC50 = 0.099 nM 10.00
CHEMBL541440 — IC50 = 0.12 nM 9.92
CHEMBL539891 — IC50 = 0.12 nM 9.92
CHEMBL552530 — IC50 = 0.12 nM 9.92
CHEMBL551337 — IC50 = 0.13 nM 9.89
CHEMBL501006 — IC50 = 0.17 nM 9.77
CHEMBL555142 — IC50 = 0.17 nM 9.77
CHEMBL126678 — IC50 = 0.18 nM 9.74
CHEMBL539196 — IC50 = 0.19 nM 9.72
CHEMBL126916 — IC50 = 0.2 nM 9.70
CHEMBL507683 — IC50 = 0.2 nM 9.70
CHEMBL564422 — IC50 = 0.26 nM 9.59
CHEMBL506225 — IC50 = 0.3 nM 9.52
CHEMBL502400 — IC50 = 0.3 nM 9.52
CHEMBL553933 — IC50 = 0.31 nM 9.51
CHEMBL554777 — IC50 = 0.31 nM 9.51
CHEMBL556740 — IC50 = 0.32 nM 9.49
CHEMBL553932 — IC50 = 0.32 nM 9.49
CHEMBL555946 — IC50 = 0.32 nM 9.49
CHEMBL538440 — IC50 = 0.32 nM 9.49
CHEMBL553898 — IC50 = 0.34 nM 9.47
CHEMBL540215 — IC50 = 0.34 nM 9.47
CHEMBL554541 — IC50 = 0.34 nM 9.47
CHEMBL420349 — IC50 = 0.35 nM 9.46
CHEMBL467163 — IC50 = 0.36 nM 9.44
CHEMBL450955 — IC50 = 0.36 nM 9.44
CHEMBL538133 — IC50 = 0.37 nM 9.43
CHEMBL556751 — IC50 = 0.38 nM 9.42
CHEMBL510577 — IC50 = 0.4 nM 9.40
CHEMBL552529 — IC50 = 0.4 nM 9.40
CHEMBL453702 — IC50 = 0.4 nM 9.40
CHEMBL444419 — IC50 = 0.4 nM 9.40
CHEMBL555945 — IC50 = 0.4 nM 9.40
CHEMBL537955 — IC50 = 0.44 nM 9.36
CHEMBL554560 — IC50 = 0.44 nM 9.36
CHEMBL553661 — IC50 = 0.45 nM 9.35
CHEMBL537956 — IC50 = 0.45 nM 9.35
CHEMBL556742 — IC50 = 0.47 nM 9.33
CHEMBL540216 — IC50 = 0.47 nM 9.33
CHEMBL554776 — IC50 = 0.47 nM 9.33
CHEMBL447258 — IC50 = 0.5 nM 9.30
CHEMBL556741 — IC50 = 0.53 nM 9.28
CHEMBL551331 — IC50 = 0.52 nM 9.28
CHEMBL555198 — IC50 = 0.57 nM 9.24
CHEMBL555197 — IC50 = 0.59 nM 9.23