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Assay Detail

CHEMBL1051616

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Functional
Cytotoxicity against human KB cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
Litaudon M, Jolly C, Le Callonec C, Cuong DD, Retailleau P, Nosjean O, Nguyen VH, Pfeiffer B, Boutin JA, Guéritte F.
J Nat Prod (2009) 72 : 1314 -1320
PubMed 19572612 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.63 9.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.82
CHEMBL542004 1 6.16
CHEMBL560651 1 6.16
CHEMBL553855 1 6.05
CHEMBL552716 1 5.77
CHEMBL538412 1 5.70
CHEMBL558462 1 5.54
CHEMBL557340 1 5.33
CHEMBL539907 1 5.27
CHEMBL538895 1 5.09
CHEMBL539908 1 4.94
CHEMBL554122 ICTEROGENIN 1 4.82
CHEMBL510691 LANTADENE A 1 4.80
CHEMBL555367 LANTADENE B 1 4.60
CHEMBL552717 1 4.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.15 nM 9.82
CHEMBL542004 IC50 = 700.0 nM 6.16
CHEMBL560651 IC50 = 700.0 nM 6.16
CHEMBL553855 IC50 = 900.0 nM 6.05
CHEMBL552716 IC50 = 1700.0 nM 5.77
CHEMBL538412 IC50 = 2000.0 nM 5.70
CHEMBL558462 IC50 = 2900.0 nM 5.54
CHEMBL557340 IC50 = 4700.0 nM 5.33
CHEMBL539907 IC50 = 5400.0 nM 5.27
CHEMBL538895 IC50 = 8200.0 nM 5.09
CHEMBL539908 IC50 = 11600.0 nM 4.94
CHEMBL554122 ICTEROGENIN IC50 = 15000.0 nM 4.82
CHEMBL510691 LANTADENE A IC50 = 15800.0 nM 4.80
CHEMBL555367 LANTADENE B IC50 = 25300.0 nM 4.60
CHEMBL552717 IC50 = 35500.0 nM 4.45