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Assay Detail

CHEMBL1051618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MCF7 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic pentacyclic triterpenoids from Combretum sundaicum and Lantana camara as inhibitors of Bcl-xL/BakBH3 domain peptide interaction.
Litaudon M, Jolly C, Le Callonec C, Cuong DD, Retailleau P, Nosjean O, Nguyen VH, Pfeiffer B, Boutin JA, Guéritte F.
J Nat Prod (2009) 72 : 1314 -1320
PubMed 19572612 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.50 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.15
CHEMBL542004 1 6.30
CHEMBL553855 1 6.22
CHEMBL560651 1 6.22
CHEMBL552716 1 5.82
CHEMBL538412 1 5.60
CHEMBL558462 1 5.34
CHEMBL539907 1 5.22
CHEMBL557340 1 5.04
CHEMBL538895 1 4.98
CHEMBL554122 ICTEROGENIN 1 4.95
CHEMBL539908 1 4.61
CHEMBL552717 1 4.37
CHEMBL555367 LANTADENE B 1 4.36
CHEMBL510691 LANTADENE A 1 4.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.7 nM 9.15
CHEMBL542004 IC50 = 500.0 nM 6.30
CHEMBL553855 IC50 = 600.0 nM 6.22
CHEMBL560651 IC50 = 600.0 nM 6.22
CHEMBL552716 IC50 = 1500.0 nM 5.82
CHEMBL538412 IC50 = 2500.0 nM 5.60
CHEMBL558462 IC50 = 4600.0 nM 5.34
CHEMBL539907 IC50 = 6000.0 nM 5.22
CHEMBL557340 IC50 = 9200.0 nM 5.04
CHEMBL538895 IC50 = 10500.0 nM 4.98
CHEMBL554122 ICTEROGENIN IC50 = 11300.0 nM 4.95
CHEMBL539908 IC50 = 24700.0 nM 4.61
CHEMBL552717 IC50 = 42500.0 nM 4.37
CHEMBL555367 LANTADENE B IC50 = 44000.0 nM 4.36
CHEMBL510691 LANTADENE A IC50 = 44700.0 nM 4.35