Assay Detail
Binding
CHEMBL1051701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IKr channel
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.07 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564757 | — | — | 1 | 5.70 |
| CHEMBL551921 | — | — | 1 | 5.58 |
| CHEMBL550242 | — | — | 1 | 5.22 |
| CHEMBL561788 | — | — | 1 | 5.22 |
| CHEMBL552061 | — | — | 1 | 5.16 |
| CHEMBL555347 | — | — | 1 | 5.10 |
| CHEMBL552402 | — | — | 1 | 5.09 |
| CHEMBL551058 | — | — | 1 | 5.05 |
| CHEMBL556487 | — | — | 1 | 5.00 |
| CHEMBL562926 | — | — | 1 | 4.60 |
| CHEMBL561379 | — | — | 1 | 4.57 |
| CHEMBL557032 | — | — | 1 | 4.57 |
| CHEMBL562869 | — | — | 1 | - |
| CHEMBL550652 | — | — | 1 | - |
| CHEMBL563732 | — | — | 1 | - |
| CHEMBL559101 | — | — | 1 | - |
| CHEMBL552196 | — | — | 1 | - |
| CHEMBL561259 | — | — | 1 | - |
| CHEMBL564547 | — | — | 1 | - |
| CHEMBL564975 | — | — | 1 | - |
| CHEMBL552382 | — | — | 2 | - |
| CHEMBL551517 | — | — | 1 | - |
| CHEMBL562822 | — | — | 1 | - |
| CHEMBL559531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564757 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL551921 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL550242 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL561788 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL552061 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL555347 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL552402 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL551058 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL556487 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL562926 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL561379 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL557032 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL562869 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL550652 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL563732 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL559101 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552196 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL561259 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL564547 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL564975 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552382 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL551517 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL562822 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL552382 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL559531 | — | IC50 | > | 30000.0 | nM | - |