Assay Detail
Binding
CHEMBL1051702
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Inhibition of human sEH
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.44 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215387 | — | — | 1 | 8.80 |
| CHEMBL551058 | — | — | 1 | 8.40 |
| CHEMBL559531 | — | — | 1 | 8.30 |
| CHEMBL555347 | — | — | 1 | 8.15 |
| CHEMBL551921 | — | — | 1 | 8.15 |
| CHEMBL564757 | — | — | 1 | 8.15 |
| CHEMBL552402 | — | — | 1 | 8.12 |
| CHEMBL550242 | — | — | 1 | 8.10 |
| CHEMBL552382 | — | — | 2 | 8.05 |
| CHEMBL561788 | — | — | 1 | 8.05 |
| CHEMBL552061 | — | — | 1 | 8.00 |
| CHEMBL557032 | — | — | 1 | 7.89 |
| CHEMBL562822 | — | — | 1 | 7.85 |
| CHEMBL556487 | — | — | 1 | 7.85 |
| CHEMBL564547 | — | — | 1 | 7.55 |
| CHEMBL551517 | — | — | 1 | 7.48 |
| CHEMBL562926 | — | — | 1 | 7.44 |
| CHEMBL561259 | — | — | 1 | 7.27 |
| CHEMBL562869 | — | — | 1 | 6.92 |
| CHEMBL552381 | — | — | 1 | 6.89 |
| CHEMBL561379 | — | — | 1 | 6.63 |
| CHEMBL564975 | — | — | 1 | 6.37 |
| CHEMBL559101 | — | — | 1 | 6.32 |
| CHEMBL552196 | — | — | 1 | 5.96 |
| CHEMBL563732 | — | — | 1 | 5.96 |
| CHEMBL550652 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215387 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL551058 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL559531 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL555347 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL551921 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL564757 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL552402 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL550242 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL552382 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL561788 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL552061 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL557032 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL556487 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL562822 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL564547 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL551517 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL562926 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL561259 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL552382 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL562869 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL552381 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL561379 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL564975 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL559101 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL552196 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL563732 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL550652 | — | IC50 | = | 8400.0 | nM | 5.08 |