Assay Detail
Functional
CHEMBL1052302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.49 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561360 | — | — | 1 | 5.85 |
| CHEMBL564469 | — | — | 1 | 5.72 |
| CHEMBL560838 | — | — | 1 | 5.70 |
| CHEMBL561162 | — | — | 1 | 5.66 |
| CHEMBL561042 | — | — | 1 | 5.42 |
| CHEMBL1197149 | — | — | 1 | 5.42 |
| CHEMBL559638 | — | — | 1 | 5.15 |
| CHEMBL562221 | — | — | 1 | 4.96 |
| CHEMBL550958 | — | — | 1 | - |
| CHEMBL560640 | — | — | 1 | - |
| CHEMBL549821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561360 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL564469 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL560838 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL561162 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL561042 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL1197149 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL559638 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL562221 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL550958 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL560640 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL549821 | — | EC50 | > | 50000.0 | nM | - |