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Assay Detail

CHEMBL1052307

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV2a.4 NS5B Cdelta21 RNA dependent RNA polymerase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A.
J Med Chem (2009) 52 : 5217 -5227
PubMed 19877603 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.11 6.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL559638 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL559638 IC50 = 770.0 nM 6.11