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Assay Detail

CHEMBL1052341

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Functional
Antibacterial activity against permeabilized polA-deficient Bacillus anthracis Sterne assessed as inhibition of DNA replication by cell based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Bacillus anthracis
Confidence 1 — Organism
Curated By Autocuration

Target

Bacillus anthracis (CHEMBL613904)
Type ORGANISM
Organism Bacillus anthracis

Publication

Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.
Aiello D, Barnes MH, Biswas EE, Biswas SB, Gu S, Williams JD, Bowlin TL, Moir DT.
Bioorg Med Chem (2009) 17 : 4466 -4476
PubMed 19477652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.34 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL560919 1 5.00
CHEMBL540680 1 4.60
CHEMBL561925 1 4.57
CHEMBL556099 1 4.52
CHEMBL558246 1 4.21
CHEMBL561121 1 4.14
CHEMBL561523 1 4.02
CHEMBL549285 1 4.00
CHEMBL559791 1 4.00
CHEMBL554576 1 -
CHEMBL559790 1 -
CHEMBL561728 1 -
CHEMBL559989 1 -
CHEMBL563047 1 -
CHEMBL561122 1 -
CHEMBL550107 1 -
CHEMBL212723 1 -
CHEMBL386313 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL560919 IC50 = 10000.0 nM 5.00
CHEMBL540680 IC50 = 25000.0 nM 4.60
CHEMBL561925 IC50 = 27000.0 nM 4.57
CHEMBL556099 IC50 = 30000.0 nM 4.52
CHEMBL558246 IC50 = 61000.0 nM 4.21
CHEMBL561121 IC50 = 73000.0 nM 4.14
CHEMBL561523 IC50 = 95000.0 nM 4.02
CHEMBL549285 IC50 = 100000.0 nM 4.00
CHEMBL559791 IC50 = 100000.0 nM 4.00
CHEMBL554576 IC50 > 100000.0 nM -
CHEMBL559790 IC50 = 107000.0 nM -
CHEMBL561728 IC50 > 100000.0 nM -
CHEMBL559989 IC50 > 100000.0 nM -
CHEMBL563047 IC50 > 100000.0 nM -
CHEMBL561122 IC50 - -
CHEMBL550107 IC50 > 100000.0 nM -
CHEMBL212723 IC50 > 100000.0 nM -
CHEMBL386313 IC50 - -