Assay Detail
Binding
CHEMBL1052345
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Inhibition of Bacillus anthracis DNA helicase DnaB expressed in Escherichia coli BL21 (DE3) assessed as strand unwinding after 30 mins by FRET assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.03 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561122 | — | — | 1 | 6.30 |
| CHEMBL561121 | — | — | 1 | 6.00 |
| CHEMBL556099 | — | — | 1 | 5.70 |
| CHEMBL561523 | — | — | 1 | 5.70 |
| CHEMBL559791 | — | — | 1 | 5.40 |
| CHEMBL212723 | — | — | 1 | 5.40 |
| CHEMBL386313 | — | — | 1 | 5.40 |
| CHEMBL559790 | — | — | 1 | 5.22 |
| CHEMBL560919 | — | — | 1 | 5.00 |
| CHEMBL549285 | — | — | 1 | 5.00 |
| CHEMBL540680 | — | — | 1 | 4.92 |
| CHEMBL559989 | — | — | 1 | 4.92 |
| CHEMBL563047 | — | — | 1 | 4.92 |
| CHEMBL550107 | — | — | 1 | 4.92 |
| CHEMBL554576 | — | — | 1 | 4.82 |
| CHEMBL558246 | — | — | 1 | 4.62 |
| CHEMBL558837 | — | — | 1 | 4.60 |
| CHEMBL561925 | — | — | 1 | 4.60 |
| CHEMBL561728 | — | — | 1 | 4.60 |
| CHEMBL551598 | — | — | 1 | 4.30 |
| CHEMBL551804 | — | — | 1 | 4.24 |
| CHEMBL558311 | — | — | 1 | 4.03 |
| CHEMBL564400 | — | — | 1 | - |
| CHEMBL562264 | — | — | 1 | - |
| CHEMBL563676 | — | — | 1 | - |
| CHEMBL552201 | — | — | 1 | - |
| CHEMBL539692 | — | — | 1 | - |
| CHEMBL556218 | — | — | 1 | - |
| CHEMBL561868 | — | — | 1 | - |
| CHEMBL108660 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561122 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL561121 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL556099 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL561523 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL559791 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL212723 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL386313 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL559790 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL560919 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL549285 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL540680 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL559989 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL563047 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL550107 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL554576 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL558246 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL561728 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL558837 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL561925 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL551598 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL551804 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL558311 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL551260 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559037 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL558312 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL550858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL550716 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559533 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108660 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL561868 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL556218 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL539692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL552201 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL563676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL562264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL564400 | — | IC50 | > | 100000.0 | nM | - |