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Assay Detail

CHEMBL1052385

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Binding
Binding affinity to rat recombinant L-FABP low affinity site expressed in Escherichia coli BL21(DE3) at 5 deg C by fluorimetric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Fatty acid-binding protein, liver (CHEMBL5738)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Probing the fibrate binding specificity of rat liver fatty acid binding protein.
Chuang S, Velkov T, Horne J, Wielens J, Chalmers DK, Porter CJ, Scanlon MJ.
J Med Chem (2009) 52 : 5344 -5355
PubMed 19663428 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 2 5.82 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL672 FENOFIBRATE 4.0 1 6.89
CHEMBL981 FENOFIBRIC ACID 4.0 1 4.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL672 FENOFIBRATE Kd = 130.0 nM 6.89
CHEMBL981 FENOFIBRIC ACID Kd = 18000.0 nM 4.75