Assay Detail
Binding
CHEMBL1052639
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Inhibition of [35S]tert-butylbicyclo[ 2.2.2]phosphorothionate binding to GABAA receptor in Wistar rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of fluorinated brassinosteroids based on alkene cross-metathesis and preliminary biological assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.72 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 7.10 |
| CHEMBL558049 | — | — | 1 | 7.00 |
| CHEMBL538884 | — | — | 1 | 6.05 |
| CHEMBL555224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207538 | BREXANOLONE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL558049 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL538884 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL555224 | — | IC50 | - | — | - |