Assay Detail
Functional
CHEMBL1052809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant GluR5 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx by luminescence reporter assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.52 | 4.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL568300 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL568300 | — | IC50 | = | 30000.0 | nM | 4.52 |