Assay Detail
Binding
CHEMBL1053023
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Inhibition of HCV1b BK NS5B Cdelta21 RNA dependent RNA polymerase Thumb site 2 R501E mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus (isolate BK) |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561360 | — | — | 1 | 7.00 |
| CHEMBL559638 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561360 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL559638 | — | IC50 | = | 500.0 | nM | 6.30 |