Assay Detail
Functional
CHEMBL1054134
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Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556074 | — | — | 1 | 9.00 |
| CHEMBL468454 | ROCAGLAOL | — | 1 | 8.40 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.34 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.00 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.92 |
| CHEMBL560526 | — | — | 1 | 5.00 |
| CHEMBL549368 | — | — | 1 | - |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556074 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL468454 | ROCAGLAOL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL560526 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL549368 | — | IC50 | - | — | - | |
| CHEMBL3545252 | DOCETAXEL | IC50 | - | — | - |