Assay Detail
Binding
CHEMBL1054181
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Displacement of [3H]nociceptin from rat ORL1 receptor expressed in african green monkey COS7 cells by competitive binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.43 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505874 | — | — | 1 | 9.68 |
| CHEMBL556388 | — | — | 1 | 9.64 |
| CHEMBL559130 | — | — | 1 | 9.60 |
| CHEMBL555757 | — | — | 1 | 9.52 |
| CHEMBL558807 | — | — | 1 | 9.51 |
| CHEMBL504587 | — | — | 1 | 9.39 |
| CHEMBL510117 | — | — | 1 | 8.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505874 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL556388 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL559130 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL555757 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL558807 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL504587 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL510117 | — | IC50 | = | 2.1 | nM | 8.68 |