Assay Detail
Functional
CHEMBL1054201
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Cytotoxicity against mouse L1210 cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.37 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL307066 | — | — | 1 | 10.70 |
| CHEMBL561196 | — | — | 1 | 10.30 |
| CHEMBL564082 | — | — | 1 | 8.30 |
| CHEMBL293412 | — | — | 1 | 8.22 |
| CHEMBL311692 | — | — | 1 | 7.70 |
| CHEMBL158873 | — | — | 1 | 7.62 |
| CHEMBL564260 | — | — | 1 | 7.60 |
| CHEMBL560738 | — | — | 1 | 7.52 |
| CHEMBL540969 | — | — | 1 | 7.48 |
| CHEMBL550806 | — | — | 1 | 7.16 |
| CHEMBL80596 | — | — | 1 | 7.10 |
| CHEMBL80827 | — | — | 1 | 7.05 |
| CHEMBL346549 | — | — | 1 | 6.96 |
| CHEMBL158515 | — | — | 1 | 6.85 |
| CHEMBL158514 | — | — | 1 | 6.70 |
| CHEMBL563286 | — | — | 1 | 6.48 |
| CHEMBL294907 | — | — | 1 | 6.48 |
| CHEMBL556809 | — | — | 1 | 5.96 |
| CHEMBL549916 | — | — | 1 | 5.85 |
| CHEMBL159242 | — | — | 1 | 5.70 |
| CHEMBL560534 | — | — | 1 | 5.50 |
| CHEMBL564832 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL307066 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL561196 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL564082 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL293412 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL311692 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL158873 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL564260 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL560738 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL540969 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL550806 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL80596 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL80827 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL346549 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL158515 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL158514 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL563286 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL294907 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL556809 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL549916 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL159242 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL560534 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL564832 | — | IC50 | = | 5000.0 | nM | 5.30 |