Assay Detail

CHEMBL1054652

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Functional

Cytotoxicity against human RPMI8226 cells after 48 hrs by resazurin assay

ChEMBL ↗

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Target

RPMI-8226 (CHEMBL614882) ↗

Open DB target context

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RPMI-8226 (CHEMBL614882) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target RPMI-8226

CHEMBL614882

Anchored from Assay target.

Protein identity RPMI-8226

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	RPMI-8226
Confidence	1 — Organism
Curated By	Autocuration

Target

RPMI-8226 (CHEMBL614882) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Antiprotealide is a natural product.

Manam RR, Macherla VR, Tsueng G, Dring CW, Weiss J, Neuteboom ST, Lam KS, Potts BC.
J Nat Prod (2009) 72 : 295 -297
PubMed 19133779 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.06	7.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL371405	MARIZOMIB	3.0	1	7.96
CHEMBL561240	ANTIPROTEALIDE	—	2	6.66

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL371405	MARIZOMIB	IC50	=	11.0	nM	7.96
CHEMBL561240	ANTIPROTEALIDE	IC50	=	220.0	nM	6.66
CHEMBL561240	ANTIPROTEALIDE	IC50	=	283.0	nM	6.55