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Assay Detail

CHEMBL1054837

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Functional
Antiviral activity against RSV assessed as inhibition of viral replication by cell based assay
ChEMBL ↗
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Respiratory syncytial virus
Confidence 1 — Organism
Curated By Autocuration

Target

Respiratory syncytial virus (CHEMBL612679) ↗
Type ORGANISM
Organism Respiratory syncytial virus

Publication

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.
Sin N, Venables BL, Combrink KD, Gulgeze HB, Yu KL, Civiello RL, Thuring J, Wang XA, Yang Z, Zadjura L, Marino A, Kadow KF, Cianci CW, Clarke J, Genovesi EV, Medina I, Lamb L, Krystal M, Meanwell NA.
Bioorg Med Chem Lett (2009) 19 : 4857 -4862
PubMed 19596574 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 80 7.00 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL553220 — — 1 8.30
CHEMBL550929 — — 1 8.14
CHEMBL551335 — — 1 8.05
CHEMBL564462 — — 1 8.00
CHEMBL562140 — — 1 8.00
CHEMBL551336 — — 1 7.92
CHEMBL556295 — — 1 7.91
CHEMBL549918 — — 1 7.90
CHEMBL558852 — — 1 7.80
CHEMBL559116 — — 1 7.78
CHEMBL561137 — — 1 7.75
CHEMBL559943 — — 1 7.72
CHEMBL562277 — — 1 7.64
CHEMBL561395 — — 1 7.64
CHEMBL562733 — — 1 7.64
CHEMBL563059 — — 1 7.58
CHEMBL564363 — — 1 7.54
CHEMBL550056 — — 1 7.54
CHEMBL560003 — — 1 7.52
CHEMBL549588 — — 1 7.52
CHEMBL560936 — — 1 7.52
CHEMBL557322 — — 1 7.51
CHEMBL564246 — — 1 7.51
CHEMBL562141 — — 1 7.37
CHEMBL556086 — — 1 7.35
CHEMBL550193 — — 1 7.34
CHEMBL556646 — — 1 7.30
CHEMBL563950 — — 1 7.30
CHEMBL562808 — — 1 7.29
CHEMBL551073 — — 1 7.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL553220 — EC50 = 5.0 nM 8.30
CHEMBL550929 — EC50 = 7.3 nM 8.14
CHEMBL551335 — EC50 = 9.0 nM 8.05
CHEMBL564462 — EC50 = 10.0 nM 8.00
CHEMBL562140 — EC50 = 10.0 nM 8.00
CHEMBL551336 — EC50 = 12.0 nM 7.92
CHEMBL556295 — EC50 = 12.4 nM 7.91
CHEMBL549918 — EC50 = 12.5 nM 7.90
CHEMBL558852 — EC50 = 16.0 nM 7.80
CHEMBL559116 — EC50 = 16.5 nM 7.78
CHEMBL561137 — EC50 = 17.9 nM 7.75
CHEMBL559943 — EC50 = 19.0 nM 7.72
CHEMBL562733 — EC50 = 22.7 nM 7.64
CHEMBL561395 — EC50 = 23.0 nM 7.64
CHEMBL562277 — EC50 = 23.0 nM 7.64
CHEMBL563059 — EC50 = 26.0 nM 7.58
CHEMBL564363 — EC50 = 29.2 nM 7.54
CHEMBL550056 — EC50 = 29.0 nM 7.54
CHEMBL560003 — EC50 = 30.0 nM 7.52
CHEMBL549588 — EC50 = 30.0 nM 7.52
CHEMBL560936 — EC50 = 30.0 nM 7.52
CHEMBL557322 — EC50 = 30.9 nM 7.51
CHEMBL564246 — EC50 = 31.2 nM 7.51
CHEMBL562141 — EC50 = 43.1 nM 7.37
CHEMBL556086 — EC50 = 45.0 nM 7.35
CHEMBL550193 — EC50 = 46.0 nM 7.34
CHEMBL563950 — EC50 = 50.0 nM 7.30
CHEMBL556646 — EC50 = 49.7 nM 7.30
CHEMBL562808 — EC50 = 51.0 nM 7.29
CHEMBL551073 — EC50 = 54.2 nM 7.27
CHEMBL557526 — EC50 = 54.6 nM 7.26
CHEMBL563264 — EC50 = 57.3 nM 7.24
CHEMBL554932 — EC50 = 59.0 nM 7.23
CHEMBL557048 — EC50 = 62.0 nM 7.21
CHEMBL560478 — EC50 = 61.9 nM 7.21
CHEMBL554064 — EC50 = 65.0 nM 7.19
CHEMBL561536 — EC50 = 64.0 nM 7.19
CHEMBL564491 — EC50 = 66.0 nM 7.18
CHEMBL562535 — EC50 = 71.0 nM 7.15
CHEMBL562536 — EC50 = 79.8 nM 7.10
CHEMBL557521 — EC50 = 79.0 nM 7.10
CHEMBL562685 — EC50 = 87.0 nM 7.06
CHEMBL561742 — EC50 = 92.8 nM 7.03
CHEMBL562885 — EC50 = 96.0 nM 7.02
CHEMBL552416 — EC50 = 106.0 nM 6.97
CHEMBL560591 — EC50 = 112.0 nM 6.95
CHEMBL564878 — EC50 = 125.0 nM 6.90
CHEMBL563332 — EC50 = 141.0 nM 6.85
CHEMBL556228 — EC50 = 147.0 nM 6.83
CHEMBL561876 — EC50 = 152.0 nM 6.82