Assay Detail
Functional
CHEMBL1055397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.23 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205924 | MORACIN O | — | 1 | 9.85 |
| CHEMBL561971 | MORACIN P | — | 1 | 9.19 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 7.24 |
| CHEMBL563553 | MULBERROFURAN H | — | 1 | 6.85 |
| CHEMBL525084 | SANGGENON O | — | 1 | 5.99 |
| CHEMBL204813 | SANGGENON C | — | 1 | 5.90 |
| CHEMBL445265 | MULBERROFURAN G | — | 1 | 5.58 |
| CHEMBL570526 | KUWANON R | — | 1 | 5.50 |
| CHEMBL564896 | ALBAFURAN A | — | 1 | 5.46 |
| CHEMBL562810 | MULBERROFURAN W | — | 1 | 5.44 |
| CHEMBL2368640 | — | — | 1 | 5.42 |
| CHEMBL517247 | MULBERROFURAN D | — | 1 | 5.39 |
| CHEMBL570475 | KUWANON J | — | 1 | 5.39 |
| CHEMBL562169 | MORACIN Q | — | 1 | 5.23 |
| CHEMBL570609 | KUWANON V | — | 1 | 5.08 |
| CHEMBL512578 | MORACIN M | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205924 | MORACIN O | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL561971 | MORACIN P | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL563553 | MULBERROFURAN H | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL525084 | SANGGENON O | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL204813 | SANGGENON C | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL445265 | MULBERROFURAN G | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL570526 | KUWANON R | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL564896 | ALBAFURAN A | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL562810 | MULBERROFURAN W | IC50 | = | 3620.0 | nM | 5.44 |
| CHEMBL2368640 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL517247 | MULBERROFURAN D | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL570475 | KUWANON J | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL562169 | MORACIN Q | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL570609 | KUWANON V | IC50 | = | 8320.0 | nM | 5.08 |
| CHEMBL512578 | MORACIN M | IC50 | > | 50000.0 | nM | - |