Assay Detail
Functional
CHEMBL1055746
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Cytotoxicity against human H460 cells after 48 hrs by cell titer-blue assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.06 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561602 | — | — | 1 | 5.29 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 5.09 |
| CHEMBL560141 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561602 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL376408 | ABT 737 | IC50 | = | 8030.0 | nM | 5.09 |
| CHEMBL560141 | — | IC50 | = | 15530.0 | nM | 4.81 |