Assay Detail
Binding
CHEMBL1055772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin polymerization
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.30 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140220 | — | — | 1 | 6.28 |
| CHEMBL49642 | INDIBULIN | 2.0 | 1 | 6.00 |
| CHEMBL558718 | — | — | 1 | 5.43 |
| CHEMBL559349 | — | — | 1 | 5.36 |
| CHEMBL525978 | — | — | 1 | 5.28 |
| CHEMBL538707 | — | — | 1 | 5.27 |
| CHEMBL562730 | — | — | 1 | 5.21 |
| CHEMBL550404 | — | — | 1 | 5.21 |
| CHEMBL562903 | — | — | 1 | 5.11 |
| CHEMBL550809 | — | — | 1 | 5.05 |
| CHEMBL562645 | — | — | 1 | 5.04 |
| CHEMBL541706 | — | — | 1 | 4.89 |
| CHEMBL552568 | — | — | 1 | 4.83 |
| CHEMBL550529 | — | — | 1 | - |
| CHEMBL552278 | — | — | 1 | - |
| CHEMBL564070 | — | — | 1 | - |
| CHEMBL559747 | — | — | 1 | - |
| CHEMBL562972 | — | — | 1 | - |
| CHEMBL559119 | — | — | 1 | - |
| CHEMBL557827 | — | — | 1 | - |
| CHEMBL559202 | — | — | 1 | - |
| CHEMBL563170 | — | — | 1 | - |
| CHEMBL556208 | — | — | 1 | - |
| CHEMBL559028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140220 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL49642 | INDIBULIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL558718 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL559349 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL525978 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL538707 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL562730 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL550404 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL562903 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL550809 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL562645 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL541706 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL552568 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL550529 | — | IC50 | - | — | - | |
| CHEMBL552278 | — | IC50 | - | — | - | |
| CHEMBL564070 | — | IC50 | - | — | - | |
| CHEMBL559747 | — | IC50 | - | — | - | |
| CHEMBL562972 | — | IC50 | - | — | - | |
| CHEMBL559119 | — | IC50 | - | — | - | |
| CHEMBL557827 | — | IC50 | - | — | - | |
| CHEMBL559202 | — | IC50 | - | — | - | |
| CHEMBL563170 | — | IC50 | - | — | - | |
| CHEMBL556208 | — | IC50 | - | — | - | |
| CHEMBL559028 | — | IC50 | - | — | - |