Assay Detail
Binding
CHEMBL1055928
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Displacement of human [125I]IL-8 from human CXCR1
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.76 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556656 | — | — | 1 | 7.68 |
| CHEMBL556862 | — | — | 1 | 7.52 |
| CHEMBL254370 | — | — | 1 | 7.40 |
| CHEMBL562286 | — | — | 1 | 7.39 |
| CHEMBL563875 | — | — | 1 | 7.27 |
| CHEMBL561812 | — | — | 1 | 6.91 |
| CHEMBL385715 | — | — | 1 | 6.68 |
| CHEMBL562781 | — | — | 1 | 6.42 |
| CHEMBL550880 | — | — | 1 | 5.91 |
| CHEMBL562950 | — | — | 1 | 5.68 |
| CHEMBL550945 | — | — | 1 | 5.55 |
| CHEMBL563129 | — | — | 1 | - |
| CHEMBL564068 | — | — | 1 | - |
| CHEMBL564029 | — | — | 1 | - |
| CHEMBL563855 | — | — | 1 | - |
| CHEMBL562207 | — | — | 1 | - |
| CHEMBL556861 | — | — | 1 | - |
| CHEMBL562670 | — | — | 1 | - |
| CHEMBL563467 | — | — | 1 | - |
| CHEMBL557466 | — | — | 1 | - |
| CHEMBL563612 | — | — | 1 | - |
| CHEMBL557877 | — | — | 1 | - |
| CHEMBL550130 | — | — | 1 | - |
| CHEMBL560089 | — | — | 1 | - |
| CHEMBL550414 | — | — | 1 | - |
| CHEMBL550006 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556656 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL556862 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL254370 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL562286 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL563875 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL561812 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL385715 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL562781 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL550880 | — | Ki | = | 1221.0 | nM | 5.91 |
| CHEMBL562950 | — | Ki | = | 2068.0 | nM | 5.68 |
| CHEMBL550945 | — | Ki | = | 2797.0 | nM | 5.55 |
| CHEMBL563129 | — | Ki | - | — | - | |
| CHEMBL564068 | — | Ki | - | — | - | |
| CHEMBL564029 | — | Ki | - | — | - | |
| CHEMBL563855 | — | Ki | - | — | - | |
| CHEMBL562207 | — | Ki | - | — | - | |
| CHEMBL556861 | — | Ki | - | — | - | |
| CHEMBL562670 | — | Ki | - | — | - | |
| CHEMBL563467 | — | Ki | - | — | - | |
| CHEMBL557466 | — | Ki | - | — | - | |
| CHEMBL563612 | — | Ki | - | — | - | |
| CHEMBL557877 | — | Ki | - | — | - | |
| CHEMBL550130 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL560089 | — | Ki | - | — | - | |
| CHEMBL550414 | — | Ki | - | — | - | |
| CHEMBL550006 | — | Ki | - | — | - |