Assay Detail
Binding
CHEMBL1056142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells after 60 mins by liquid scintillation counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.17 | 10.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147511 | — | — | 1 | 10.31 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 10.10 |
| CHEMBL584791 | — | — | 1 | 9.89 |
| CHEMBL566346 | — | — | 1 | 9.54 |
| CHEMBL565679 | — | — | 1 | 9.38 |
| CHEMBL584790 | — | — | 1 | 9.33 |
| CHEMBL582930 | — | — | 1 | 9.21 |
| CHEMBL566762 | — | — | 1 | 9.03 |
| CHEMBL575031 | — | — | 1 | 8.66 |
| CHEMBL584792 | — | — | 1 | 8.47 |
| CHEMBL575647 | — | — | 1 | 8.33 |
| CHEMBL573918 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147511 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 0.079 | nM | 10.10 |
| CHEMBL584791 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL566346 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL565679 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL584790 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL582930 | — | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL566762 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL575031 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL584792 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL575647 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL573918 | — | Ki | = | 18.0 | nM | 7.75 |