Assay Detail
Functional
CHEMBL1056149
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Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 8.56 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147511 | — | — | 1 | 9.07 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.89 |
| CHEMBL584791 | — | — | 1 | 8.80 |
| CHEMBL566346 | — | — | 1 | 8.55 |
| CHEMBL565679 | — | — | 1 | 8.31 |
| CHEMBL584790 | — | — | 1 | 8.19 |
| CHEMBL582930 | — | — | 1 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147511 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL301160 | BUTORPHAN | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL584791 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL566346 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL565679 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL584790 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL582930 | — | EC50 | = | 7.3 | nM | 8.14 |