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Assay Detail

CHEMBL1056355

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Binding
Inhibition of HDAC
ChEMBL ↗
80
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment.
Chen Y, Li H, Tang W, Zhu C, Jiang Y, Zou J, Yu Q, You Q.
Eur J Med Chem (2009) 44 : 2868 -2876
PubMed 19136179 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 80 6.55 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99456 — — 1 8.70
CHEMBL95552 — — 1 8.40
CHEMBL99216 — — 1 8.35
CHEMBL95313 — — 1 8.30
CHEMBL451182 — — 1 8.22
CHEMBL95535 — — 1 8.10
CHEMBL96984 — — 1 8.07
CHEMBL99877 — — 1 8.02
CHEMBL95835 — — 1 7.82
CHEMBL95747 — — 1 7.60
CHEMBL319738 — — 1 7.46
CHEMBL320909 — — 1 7.46
CHEMBL95241 — — 1 7.35
CHEMBL319070 — — 1 7.35
CHEMBL95553 — — 2 7.22
CHEMBL95959 — — 1 7.19
CHEMBL149606 — — 2 7.15
CHEMBL318642 — — 2 7.12
CHEMBL98669 — — 2 7.05
CHEMBL95885 — — 1 7.02
CHEMBL97272 — — 2 7.00
CHEMBL96966 — — 2 7.00
CHEMBL98346 — — 2 7.00
CHEMBL95850 — — 2 7.00
CHEMBL95195 — — 2 7.00
CHEMBL146202 — — 2 6.99
CHEMBL99810 — — 1 6.87
CHEMBL98911 — — 1 6.82
CHEMBL317814 — — 2 6.70
CHEMBL317570 — — 2 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99456 — IC50 = 1.995 nM 8.70
CHEMBL95552 — IC50 = 3.981 nM 8.40
CHEMBL99216 — IC50 = 4.467 nM 8.35
CHEMBL95313 — IC50 = 5.012 nM 8.30
CHEMBL451182 — IC50 = 6.026 nM 8.22
CHEMBL95535 — IC50 = 7.943 nM 8.10
CHEMBL96984 — IC50 = 8.511 nM 8.07
CHEMBL99877 — IC50 = 9.55 nM 8.02
CHEMBL95835 — IC50 = 15.14 nM 7.82
CHEMBL95747 — IC50 = 25.12 nM 7.60
CHEMBL320909 — IC50 = 34.67 nM 7.46
CHEMBL319738 — IC50 = 34.67 nM 7.46
CHEMBL319070 — IC50 = 44.67 nM 7.35
CHEMBL95241 — IC50 = 44.67 nM 7.35
CHEMBL95553 — IC50 = 60.0 nM 7.22
CHEMBL95553 — IC50 = 60.26 nM 7.22
CHEMBL95959 — IC50 = 64.57 nM 7.19
CHEMBL149606 — IC50 = 70.79 nM 7.15
CHEMBL149606 — IC50 = 71.4 nM 7.15
CHEMBL318642 — IC50 = 75.86 nM 7.12
CHEMBL318642 — IC50 = 75.0 nM 7.12
CHEMBL98669 — IC50 = 90.0 nM 7.05
CHEMBL98669 — IC50 = 89.13 nM 7.05
CHEMBL95885 — IC50 = 95.5 nM 7.02
CHEMBL96966 — IC50 = 100.0 nM 7.00
CHEMBL98346 — IC50 = 100.0 nM 7.00
CHEMBL95195 — IC50 = 100.0 nM 7.00
CHEMBL97272 — IC50 = 100.0 nM 7.00
CHEMBL97272 — IC50 = 100.0 nM 7.00
CHEMBL95195 — IC50 = 100.0 nM 7.00
CHEMBL95850 — IC50 = 100.0 nM 7.00
CHEMBL95850 — IC50 = 100.0 nM 7.00
CHEMBL98346 — IC50 = 100.0 nM 7.00
CHEMBL96966 — IC50 = 100.0 nM 7.00
CHEMBL146202 — IC50 = 103.0 nM 6.99
CHEMBL146202 — IC50 = 102.33 nM 6.99
CHEMBL99810 — IC50 = 134.9 nM 6.87
CHEMBL98911 — IC50 = 151.36 nM 6.82
CHEMBL317814 — IC50 = 199.53 nM 6.70
CHEMBL317814 — IC50 = 200.0 nM 6.70
CHEMBL95849 — IC50 = 302.0 nM 6.52
CHEMBL95849 — IC50 = 300.0 nM 6.52
CHEMBL317570 — IC50 = 302.0 nM 6.52
CHEMBL317570 — IC50 = 300.0 nM 6.52
CHEMBL95990 — IC50 = 446.68 nM 6.35
CHEMBL95916 — IC50 = 501.19 nM 6.30
CHEMBL97384 — IC50 = 602.56 nM 6.22
CHEMBL316457 — IC50 = 602.56 nM 6.22
CHEMBL97387 — IC50 = 602.56 nM 6.22
CHEMBL95510 — IC50 = 602.56 nM 6.22