Assay Detail
Functional
CHEMBL1056544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556648 | — | — | 1 | 7.80 |
| CHEMBL494462 | — | — | 1 | 7.72 |
| CHEMBL563893 | — | — | 1 | 7.70 |
| CHEMBL557121 | — | — | 1 | 7.68 |
| CHEMBL557458 | — | — | 1 | 7.58 |
| CHEMBL556439 | — | — | 1 | 7.55 |
| CHEMBL551613 | — | — | 1 | 7.35 |
| CHEMBL561882 | — | — | 1 | 7.33 |
| CHEMBL562873 | — | — | 1 | 7.18 |
| CHEMBL550472 | — | — | 1 | 7.16 |
| CHEMBL561805 | — | — | 1 | 7.09 |
| CHEMBL551412 | — | — | 1 | 7.05 |
| CHEMBL562280 | — | — | 1 | 7.04 |
| CHEMBL561339 | ADL-5747 FREE BASE | 2.0 | 1 | 7.03 |
| CHEMBL550261 | — | — | 1 | 7.00 |
| CHEMBL551536 | — | — | 1 | 7.00 |
| CHEMBL550063 | — | — | 1 | 6.96 |
| CHEMBL551413 | — | — | 1 | 6.96 |
| CHEMBL557054 | — | — | 1 | 6.82 |
| CHEMBL551615 | — | — | 1 | 6.72 |
| CHEMBL564922 | — | — | 1 | 6.70 |
| CHEMBL551414 | — | — | 1 | 6.62 |
| CHEMBL561138 | — | — | 1 | 6.57 |
| CHEMBL557257 | — | — | 1 | 6.51 |
| CHEMBL562478 | — | — | 1 | 6.44 |
| CHEMBL562898 | — | — | 1 | 6.43 |
| CHEMBL550471 | — | — | 1 | 6.38 |
| CHEMBL563137 | — | — | 1 | 6.35 |
| CHEMBL563700 | — | — | 1 | 6.32 |
| CHEMBL550669 | — | — | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556648 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL494462 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL563893 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL557121 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL557458 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL556439 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL551613 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL561882 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL562873 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL550472 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL561805 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL551412 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL562280 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL561339 | ADL-5747 FREE BASE | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL551536 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL550261 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL550063 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL551413 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL557054 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL551615 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL564922 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL551414 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL561138 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL557257 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL562478 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL562898 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL550471 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL563137 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL563700 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL550669 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL559414 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL556923 | — | EC50 | - | — | - |