Assay Detail
Binding
CHEMBL1056547
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Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.12 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562478 | — | — | 1 | 6.41 |
| CHEMBL550063 | — | — | 1 | 6.25 |
| CHEMBL551412 | — | — | 1 | 6.10 |
| CHEMBL551613 | — | — | 1 | 6.05 |
| CHEMBL551413 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562478 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL550063 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL551412 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL551613 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL551413 | — | Ki | = | 1600.0 | nM | 5.80 |