Assay Detail
Functional
CHEMBL1056701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARalpha expressed in african green monkey COS7 cells by Gal4 transactivation assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.66 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551479 | — | — | 1 | 7.96 |
| CHEMBL561544 | — | — | 1 | 7.68 |
| CHEMBL564017 | — | — | 1 | 7.60 |
| CHEMBL550332 | — | — | 1 | 7.31 |
| CHEMBL558141 | — | — | 1 | 7.25 |
| CHEMBL557342 | — | — | 1 | 7.07 |
| CHEMBL560484 | — | — | 1 | 7.05 |
| CHEMBL563351 | — | — | 1 | 6.96 |
| CHEMBL563546 | — | — | 1 | 6.82 |
| CHEMBL558072 | — | — | 1 | 6.72 |
| CHEMBL551420 | — | — | 1 | 6.66 |
| CHEMBL549723 | — | — | 1 | 6.60 |
| CHEMBL552347 | — | — | 1 | 6.54 |
| CHEMBL551884 | — | — | 1 | 6.41 |
| CHEMBL560205 | — | — | 1 | 6.26 |
| CHEMBL562786 | — | — | 1 | 6.22 |
| CHEMBL559752 | — | — | 1 | 5.82 |
| CHEMBL551480 | — | — | 1 | 5.77 |
| CHEMBL561284 | — | — | 1 | 5.70 |
| CHEMBL561006 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551479 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL561544 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL564017 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL550332 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL558141 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL557342 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL560484 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL563351 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL563546 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL558072 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL551420 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL549723 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL552347 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL551884 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL560205 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL562786 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL559752 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL551480 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL561284 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL561006 | — | EC50 | = | 13800.0 | nM | 4.86 |