Assay Detail
Functional
CHEMBL1056786
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.29 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559122 | — | — | 1 | 7.35 |
| CHEMBL557209 | — | — | 1 | 7.30 |
| CHEMBL564086 | — | — | 1 | 7.29 |
| CHEMBL552078 | — | — | 1 | 7.16 |
| CHEMBL224025 | — | — | 1 | 7.11 |
| CHEMBL555134 | — | — | 1 | 7.02 |
| CHEMBL389869 | — | — | 1 | 6.96 |
| CHEMBL551215 | — | — | 1 | 6.89 |
| CHEMBL550201 | — | — | 1 | 6.75 |
| CHEMBL554069 | — | — | 1 | 6.62 |
| CHEMBL224260 | — | — | 1 | 6.60 |
| CHEMBL434743 | — | — | 1 | 6.57 |
| CHEMBL387860 | — | — | 1 | 6.42 |
| CHEMBL225449 | — | — | 1 | 6.36 |
| CHEMBL561683 | — | — | 1 | 6.21 |
| CHEMBL559339 | — | — | 1 | 6.16 |
| CHEMBL556237 | — | — | 1 | 6.06 |
| CHEMBL559324 | — | — | 1 | 6.00 |
| CHEMBL538145 | — | — | 1 | 6.00 |
| CHEMBL223654 | — | — | 1 | 5.97 |
| CHEMBL550533 | — | — | 1 | 5.92 |
| CHEMBL556306 | — | — | 1 | 5.80 |
| CHEMBL549450 | — | — | 1 | 5.78 |
| CHEMBL224312 | — | — | 1 | 5.43 |
| CHEMBL563171 | — | — | 1 | 5.42 |
| CHEMBL561402 | — | — | 1 | 5.38 |
| CHEMBL538889 | — | — | 1 | 5.38 |
| CHEMBL563456 | — | — | 1 | 5.33 |
| CHEMBL551617 | — | — | 1 | 5.23 |
| CHEMBL565037 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559122 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL557209 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL564086 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL552078 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL224025 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL555134 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL389869 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL551215 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL550201 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL554069 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL224260 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL434743 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL387860 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL225449 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL561683 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL559339 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL556237 | — | IC50 | = | 877.0 | nM | 6.06 |
| CHEMBL559324 | — | IC50 | = | 991.0 | nM | 6.00 |
| CHEMBL538145 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL223654 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL550533 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL556306 | — | IC50 | = | 1566.0 | nM | 5.80 |
| CHEMBL549450 | — | IC50 | = | 1652.0 | nM | 5.78 |
| CHEMBL224312 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL563171 | — | IC50 | = | 3806.0 | nM | 5.42 |
| CHEMBL561402 | — | IC50 | = | 4145.0 | nM | 5.38 |
| CHEMBL538889 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL563456 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL551617 | — | IC50 | = | 5936.0 | nM | 5.23 |
| CHEMBL565037 | — | IC50 | - | — | - | |
| CHEMBL76 | CHLOROQUINE | IC50 | > | 250.0 | nM | - |
| CHEMBL552283 | — | IC50 | > | 10000.0 | nM | - |