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Assay Detail

CHEMBL1056791

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Binding
Inhibition of Plasmodium falciparum falcipain-2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.
Kouznetsov VV, Gómez-Barrio A.
Eur J Med Chem (2009) 44 : 3091 -3113
PubMed 19361896 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.45 6.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL434743 1 6.20
CHEMBL223654 1 6.14
CHEMBL224312 1 5.65
CHEMBL225449 1 5.58
CHEMBL224025 1 5.50
CHEMBL564086 1 4.93
CHEMBL554069 1 4.83
CHEMBL555134 1 4.75
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL565037 1 -
CHEMBL224260 1 -
CHEMBL389869 1 -
CHEMBL387860 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL434743 IC50 = 630.0 nM 6.20
CHEMBL223654 IC50 = 720.0 nM 6.14
CHEMBL224312 IC50 = 2250.0 nM 5.65
CHEMBL225449 IC50 = 2600.0 nM 5.58
CHEMBL224025 IC50 = 3160.0 nM 5.50
CHEMBL564086 IC50 = 11640.0 nM 4.93
CHEMBL554069 IC50 = 14650.0 nM 4.83
CHEMBL555134 IC50 = 17620.0 nM 4.75
CHEMBL76 CHLOROQUINE IC50 - -
CHEMBL565037 IC50 - -
CHEMBL224260 IC50 > 20000.0 nM -
CHEMBL389869 IC50 > 20000.0 nM -
CHEMBL387860 IC50 > 20000.0 nM -