Assay Detail
Binding
CHEMBL1057247
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Inhibition of DPP4
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.11 | 8.46 |
| Ki | 1 | 9.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 9.22 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 8.46 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 18.0 | nM | 7.75 |