Assay Detail
Binding
CHEMBL1057955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused recombinant CDK5/p25 expressed in Escherichia coli after 30 mins by scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Identification of potential cellular targets of aloisine A by affinity chromatography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75680 | ALOISINE A | — | 1 | 6.70 |
| CHEMBL560453 | — | — | 1 | 6.18 |
| CHEMBL551510 | — | — | 1 | 4.30 |
| CHEMBL560452 | N-METHYL-ALOISINE A | — | 1 | - |
| CHEMBL557499 | — | — | 1 | - |
| CHEMBL564656 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75680 | ALOISINE A | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL560453 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL551510 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL560452 | N-METHYL-ALOISINE A | IC50 | = | 160000.0 | nM | - |
| CHEMBL557499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL564656 | — | IC50 | > | 10000.0 | nM | - |