Assay Detail
Binding
CHEMBL1058022
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SGK1-mediated epithelial sodium channel activity in human M-1 cells assessed as short circuit current by whole cell electrophysiological transepithelial experiment
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL2343) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.02 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL564555 | — | — | 1 | 6.24 |
| CHEMBL558642 | GSK-650394 | — | 1 | 6.24 |
| CHEMBL550110 | — | — | 1 | 6.15 |
| CHEMBL549906 | — | — | 1 | 6.06 |
| CHEMBL561526 | — | — | 1 | 6.06 |
| CHEMBL550795 | — | — | 1 | 5.89 |
| CHEMBL541759 | — | — | 1 | 5.84 |
| CHEMBL562931 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL564555 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL550110 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL549906 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL561526 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL550795 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL541759 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL562931 | — | IC50 | = | 2000.0 | nM | 5.70 |