Assay Detail
Functional
CHEMBL1058176
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Antiproliferative activity against human SW48 cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW48 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.00 |
| CHEMBL562903 | — | — | 1 | 7.30 |
| CHEMBL525978 | — | — | 1 | 6.70 |
| CHEMBL559349 | — | — | 1 | 6.70 |
| CHEMBL562730 | — | — | 1 | 6.30 |
| CHEMBL538707 | — | — | 1 | 6.05 |
| CHEMBL559202 | — | — | 1 | 5.68 |
| CHEMBL550404 | — | — | 1 | 5.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL562903 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL525978 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL559349 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL562730 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL538707 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL559202 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL550404 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 4400.0 | nM | 5.36 |