Assay Detail
Binding
CHEMBL1058320
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Inhibition of PDE6
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.73 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538896 | — | — | 1 | 8.22 |
| CHEMBL556514 | — | — | 1 | 8.00 |
| CHEMBL556863 | — | — | 1 | 7.94 |
| CHEMBL560408 | — | — | 1 | 7.60 |
| CHEMBL560687 | — | — | 1 | 7.50 |
| CHEMBL563130 | — | — | 1 | 7.47 |
| CHEMBL558338 | — | — | 1 | 7.44 |
| CHEMBL550817 | — | — | 1 | 7.38 |
| CHEMBL561952 | — | — | 1 | 7.14 |
| CHEMBL560609 | — | — | 1 | 6.95 |
| CHEMBL557755 | — | — | 1 | 6.94 |
| CHEMBL557266 | — | — | 1 | 6.82 |
| CHEMBL550007 | — | — | 1 | 6.71 |
| CHEMBL559889 | — | — | 1 | 6.62 |
| CHEMBL564374 | — | — | 1 | 6.50 |
| CHEMBL558729 | — | — | 1 | 6.46 |
| CHEMBL560545 | — | — | 1 | 6.43 |
| CHEMBL557467 | — | — | 1 | 6.34 |
| CHEMBL563661 | — | — | 1 | 6.06 |
| CHEMBL557059 | — | — | 1 | 6.04 |
| CHEMBL562208 | — | — | 1 | 6.04 |
| CHEMBL550131 | — | — | 1 | 6.01 |
| CHEMBL551948 | — | — | 1 | 5.94 |
| CHEMBL561088 | — | — | 1 | 5.93 |
| CHEMBL563669 | — | — | 1 | 5.92 |
| CHEMBL561548 | — | — | 1 | 5.73 |
| CHEMBL552025 | — | — | 1 | 5.70 |
| CHEMBL563637 | — | — | 1 | - |
| CHEMBL558466 | — | — | 1 | - |
| CHEMBL562756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538896 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL556514 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL556863 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL560408 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL560687 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL563130 | — | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL558338 | — | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL550817 | — | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL561952 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL560609 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL557755 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL557266 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL550007 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL559889 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL564374 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL558729 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL560545 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL557467 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL563661 | — | IC50 | = | 871.0 | nM | 6.06 |
| CHEMBL557059 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL562208 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL550131 | — | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL551948 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL561088 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL563669 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL561548 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL552025 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL563637 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL558466 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL562756 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL550478 | — | IC50 | - | — | - | |
| CHEMBL565116 | — | IC50 | - | — | - | |
| CHEMBL565024 | — | IC50 | - | — | - |